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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
 

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Article DOI: 10.3791/59195-v • 07:29 min • April 22nd, 2019
April 22nd, 2019 •
1, 1, 1, 1, 1,2,3, 1
1Department of Radiation Oncology, University of Colorado Denver - Anschutz Medical Campus, 2Department of Anesthesiology, University of Colorado Denver - Anschutz Medical Campus, 3Division of Radiology, University of Colorado Denver - Anschutz Medical Campus

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Here we present a reproducible method for developing an orthotopic murine model of head and neck squamous cell carcinoma. Tumors demonstrate clinically relevant histopathological features of the disease, including necrosis, poor differentiation, nodal metastases, and immune infiltration. Tumor-bearing mice develop clinically relevant symptoms including dysphagia, jaw displacement, and weight loss.

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Keywords: Intramucosal Inoculation Squamous Cell Carcinoma Tumor Immune Profiling Treatment Response Assessment Head And Neck Cancer Tumor Microenvironment Treatment Resistance Tumor Cell Culture Trypsin DMEM F12 Medium Basement Membrane Matrix Tumor Volume Tumor Growth
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