Waiting
Processando Login

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Medicine / Induction and Characterization of Pulmonary…
JoVE Journal
Medicine

É necessário ter uma assinatura JoVE para assistir este Faça login ou comece sua avaliação gratuita.

JoVE Journal Medicine
Induction and Characterization of Pulmonary Hypertension in Mice using the Hypoxia/SU5416 Model
 

Induction and Characterization of Pulmonary Hypertension in Mice using the Hypoxia/SU5416 Model

Article DOI: 10.3791/59252-v • 07:10 min • June 3rd, 2020
June 3rd, 2020 •
1, 2, 1, 1
1Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, 2Phospholamban Foundation

Capítulos

Resumo
Automatic Translation

This protocol describes the induction of pulmonary hypertension (PH) in mice based on the exposure to hypoxia and the injection of a VEGF receptor antagonist. The animals develop PH and right ventricular (RV) hypertrophy 3 weeks after the initiation of the protocol. The functional and morphometrical characterization of the model is also presented.

Tags

Pulmonary Hypertension Mice Induction Characterization Hypoxia/SU5416 Model Functional Measurements Right Ventricle Sugen Hypoxia Model Hallmarks Pathways Development Of The Disease Targets Therapeutic Potential Nitrogen Tanks Hypoxic Chamber Oxygen Controller SU5416 Solution Syringe Needle Restrain Subcutaneously Flank Skin Fold Microliters Ventilated Hypoxia Chamber Oxygen Sensor
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter