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Induction and Characterization of Pulmonary Hypertension in Mice using the Hypoxia/SU5416 Model
 

Induction and Characterization of Pulmonary Hypertension in Mice using the Hypoxia/SU5416 Model

Article DOI: 10.3791/59252-v • 07:10 min • June 3rd, 2020
June 3rd, 2020 •
1, 2, 1, 1
1Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, 2Phospholamban Foundation

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Resumo
Automatic Translation

This protocol describes the induction of pulmonary hypertension (PH) in mice based on the exposure to hypoxia and the injection of a VEGF receptor antagonist. The animals develop PH and right ventricular (RV) hypertrophy 3 weeks after the initiation of the protocol. The functional and morphometrical characterization of the model is also presented.

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Keywords: Pulmonary Hypertension Hypoxia/SU5416 Model Right Ventricle Induction Procedure SU5416 Injection Hypoxia Exposure Pressure Measurement Pressure Volume Catheter Anesthesia Temperature Monitoring
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