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Cancer Research

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JoVE Journal Cancer Research
In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function
 

In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function

Article DOI: 10.3791/59275-v • 08:04 min • February 27th, 2019
February 27th, 2019 •
1,2, 1, 1, 1, *1, *1
1Department of Hematology & Hematopoietic Cell Transplantation, T Cell Therapeutics Research Laboratory, City of Hope Beckman Research Institute and Medical Center, 2Irell and Manella Graduate School of Biological Sciences, City of Hope Beckman Research Institute and Medical Center
* These authors contributed equally

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Resumo
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Here, we describe an in vitro co-culture method to recursively challenge tumor-targeted T cells, which allows for phenotypic and functional analysis of antitumor T cell activity.

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In Vitro Tumor Cell Rechallenge Predictive Evaluation Chimeric Antigen Receptor T Cell CAR T Cells Anti-tumor Function In Vitro Technique High Throughput Screening Differentiation CAR T Cell Products Glioblastoma Tumorspheres Coculture Medium Centrifugation Tumor Cell Suspensions CAR Positive T Cells Tissue Culture Plate
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