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A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity
 

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity

Article DOI: 10.3791/59616-v • 08:04 min • June 11th, 2019
June 11th, 2019 •
*1, *1, 2, 1, 3, 1,2
1Comprehensive Transplant Center, Northwestern University, 2Department of surgery, Feinberg School of Medicine, Northwestern University, 3Weinberg art and science college, Northwestern University
* These authors contributed equally

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Resumo
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This protocol details the surgical steps of a mouse model of vascularized heterotopic spleen transplantation, a technically challenging model that can serve as a powerful tool in studying the fate and longevity of spleen cells, the mechanisms of distinct spleen cell populations in disease progression, and transplant immunity.

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Keywords: Mouse Model Vascularized Heterotopic Spleen Transplantation Spleen Cell Biology Transplant Immunity Congenic Mice Spleen Cells Inflammatory Disease Surgical Procedure Donor Mouse Abdominal Surgery Spleen Graft Heparinized Saline Celiac Artery Portal Vein Splenic Vein Pancreatic Tissue
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