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Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
 

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Article DOI: 10.3791/59701-v • 10:21 min • August 8th, 2019
August 8th, 2019 •
1, 2, 3, 3, 4, 2, 1, *3, *3
1Institute of Anatomy, Rostock University Medical Center, 2Department of Nuclear Medicine, Rostock University Medical Center, 3Core Facility Multimodal Small Animal Imaging, Rostock University Medical Center, 4Rudolf-Zenker-Institute for Experimental Surgery, Rostock University Medical Center
* These authors contributed equally

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Here a protocol for continuous blood sampling during PET/CT imaging of rats to measure the arterial input function (AIF) is described. The catheterization, the calibration and setup of the system and the data analysis of the blood radioactivity are demonstrated. The generated data provide input parameters for subsequent bio-kinetic modeling.

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Keywords: Continuous Blood Sampling Small Animal PET/CT Arterial Input Function Extracorporeal Arteriovenous Shunt Biokinetic Modeling Cross-calibration Femoral Vein Femoral Artery Catheter Placement Microsurgery
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