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Solid Phase 11C-Methylation, Purification and Formulation for the Production of PET Tracers
 

Solid Phase 11C-Methylation, Purification and Formulation for the Production of PET Tracers

Article DOI: 10.3791/60237-v • 09:25 min • October 24th, 2019
October 24th, 2019 •
*1, *1, 1, 1, 1, 1,2
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 2Department of Neurology and Neurosurgery, McGill University
* These authors contributed equally

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Resumo
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We report an efficient carbon-11 radiolabeling technique to produce clinically relevant tracers for Positron Emission Tomography (PET) using solid phase extraction cartridges. 11C-methylating agent is passed through a cartridge preloaded with precursor and successive elution with aqueous ethanol provides chemically and radiochemically pure PET tracers in high radiochemical yields.

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Keywords: 11C-methylation Solid Phase Extraction PET Tracer Radiochemistry Alzheimer's Disease MGlu5 Receptor Acetate Buffer Ethanol Solution TC18 Cartridge Precursor Automation GMP
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