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Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
 

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

Article DOI: 10.3791/60360-v • 07:07 min • February 10th, 2020
February 10th, 2020 •
1, 1,2,3
1Fralin Biomedical Research Institute at Virginia Tech Carilion, 2School of Neuroscience, Virginia Tech, 3Department of Biological Sciences, Virginia Tech

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Resumo
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This systematic protocol describes a new animal model of post-traumatic epilepsy after repetitive mild traumatic brain injury. The first part details steps for traumatic brain injury induction using a modified weight drop model. The second part provides instructions on the surgical approach for single- and multi-channel electroencephalographic data acquisition systems.

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Keywords: Post-traumatic Epilepsy Mouse Model Traumatic Brain Injury Diffuse Injury Biomarkers Treatments Mild Traumatic Brain Injury Concussion EEG Electrode Implantation Stereotactic Apparatus Periosteum Cranium High-speed Drill
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