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Osteoarthritis Pain Model Induced by Intra-Articular Injection of Mono-Iodoacetate in Rats
 

Osteoarthritis Pain Model Induced by Intra-Articular Injection of Mono-Iodoacetate in Rats

Article DOI: 10.3791/60649-v • 08:09 min • May 20th, 2020
May 20th, 2020 •
1,2, 1,2, 1,2, 1, 1, 1
1The First Affiliated Hospital, Zhejiang Chinese Medical University, 2College of Pharmaceutical Science, Zhejiang Chinese Medical University

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This study describes the method of intra-articular injection of mono-iodoacetate in rats and discusses the resulting pain-related behaviors and histopathological changes, which provide references for future applications.

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Keywords: Osteoarthritis Pain Model Mono-iodoacetate Intra-articular Injection Rats Paw Withdrawal Threshold Thermal Withdrawal Latency Behavioral Testing
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