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Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
 

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Article DOI: 10.3791/61139-v • 09:09 min • June 23rd, 2020
June 23rd, 2020 •
1,2, 1, 1, 3, 3, 3, 3
1College of Life Sciences, Xinyang Normal University, 2Department of Imaging & Pathology, University of Leuven and Oral & Maxillofacial Surgery, University Hospitals Leuven, 3Analysis & Testing Center, Xinyang Normal University

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In this protocol, doxorubicin-loaded AS1411-g-PEI-g-PEG modified gold nanoparticles are synthesized via three-step amide reactions. Then, doxorubicin is loaded and delivered to target cancer cells for cancer therapy.

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Keywords: Doxorubicin Drug Delivery Gold Nanoparticles Aptamer PEI-g-PEG CT-PEG Targeted Drug Delivery Cancer Treatment Drug Resistance Toxicity
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