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Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
 

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Article DOI: 10.3791/62327-v • 06:22 min • April 7th, 2021
April 7th, 2021 •
*1, *1, 2, 1, 1, 1, 1, 2, 1
1Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin and Berlin Institute of Health Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, 2Chair for Medical Information Technology, RWTH Aachen University
* These authors contributed equally

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A combination of surfactant washout using 0.9% saline (35 mL/kg body weight, 37 °C) and high tidal volume ventilation with low PEEP to cause moderate ventilator induced lung injury (VILI) results in experimental acute respiratory distress syndrome (ARDS). This method provides a model of lung injury with low/limited recruitability to study the effect of various ventilation strategies for extended periods.

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Keywords: ARDS Surfactant Depletion Injurious Ventilation Lung Injury Recruitability Ventilation Strategies Mechanical Ventilation Anesthesia Pulmonary Artery Catheter Pressure Monitoring
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