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JoVE Journal Bioengineering
Fabrication and Characterization of Layer-By-Layer Janus Base Nano-Matrix to Promote Cartilage Regeneration
 

Fabrication and Characterization of Layer-By-Layer Janus Base Nano-Matrix to Promote Cartilage Regeneration

Article DOI: 10.3791/63984-v • 08:55 min • July 6th, 2022
July 6th, 2022 •
*1, *1, 1
1Department of Biomedical Engineering, University of Connecticut
* These authors contributed equally

Capítulos

Resumo
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This protocol describes the assembly of a layer-by-layer Janus base nano-matrix (JBNm) scaffold by adding Janus base nanotubes (JBNts), matrilin-3, and Transforming Growth Factor Beta-1 (TGF-β1) sequentially. The JBNm was fabricated and characterized; additionally, it displayed excellent bioactivity, encouraging cell functions such as adhesion, proliferation, and differentiation.

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Keywords: Layer-by-layer Janus Base Nano-Matrix JBNm TGF-B1 Matrilin-3 Cartilage Regeneration Growth Factor Encapsulation Localized Chondrogenesis Homeostatic Microenvironment Spectrophotometry Protein Labeling
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