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JoVE Journal Cancer Research
X-Ray Visualization of Intraductal Ethanol-Based Ablative Treatment for Prevention of Breast Cancer in Rat Models
 

X-Ray Visualization of Intraductal Ethanol-Based Ablative Treatment for Prevention of Breast Cancer in Rat Models

Article DOI: 10.3791/64042-v • 12:57 min • December 9th, 2022
December 9th, 2022 •
1,2, 1,3, 1,2, 1,4, 2,5, 2,6, 7, 2, 1,2
1Precision Health Program, Michigan State University, 2Department of Radiology, Michigan State University, 3Department of Pharmacology & Toxicology, Michigan State University, 4College of Osteopathic Medicine, Michigan State University, 5TechInsights Inc., 6IQ Advanced Molecular Imaging Facility, Michigan State University, 7Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University

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A procedure for the delivery of a chemical ablative solution to the rat mammary ductal tree for image-guided preventive treatment of breast cancer is described. Mammary epithelial cells can be targeted with minimal collateral tissue damage through cannulation directly into the nipple opening and intraductal infusion of a 70% ethanol-based ablative solution.

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Keywords: X-Ray Visualization Intraductal Ethanol-Based Ablative Treatment Breast Cancer Prevention Rat Models Mammary Ductal Tree Ethyl Cellulose Carprofen Sucralose Gel Cups MicroCT Scans 3D Reconstructions
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