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JoVE Journal Bioengineering
Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall
 

Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall

Article DOI: 10.3791/64122-v • 11:47 min • July 6th, 2022
July 6th, 2022 •
*1, *1, *1, 1, 2, 1, 1, 1, 1, 1, 1, 1, 1
1Department of Cardiac Surgery and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 2Institutes of Biomedical Sciences and the Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College, Fudan University
* These authors contributed equally

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Here, we developed a human aorta smooth muscle cell organ-on-a-chip model to replicate the in vivo biomechanical strain of smooth muscle cells in the human aortic wall.

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Keywords: Human Aorta Smooth Muscle Cells Organ-on-a-chip Biomechanical Strain Aortic Wall In Vitro Model Drug Screening Personalized Medicine Aortic Diseases Cell Culture PDMS Mold Design
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