Waiting
Processando Login

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Bioengineering / Hybrid Cell Analysis System to Assess Structural…
JoVE Journal
Bioengineering

É necessário ter uma assinatura JoVE para assistir este Faça login ou comece sua avaliação gratuita.

JoVE Journal Bioengineering
Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation
 

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation

Article DOI: 10.3791/64283-v • 08:03 min • October 20th, 2022
October 20th, 2022 •
1, 1, 1, 2, 2, 2, 2, 2, 2
1innoVitro GmbH, 2Nanion Technologies GmbH

Capítulos

Resumo
Automatic Translation

The analysis of changes in contractile function and cellular integrity of human iPSC-derived cardiomyocytes is of immense importance for nonclinical drug development. A hybrid 96-well cell analysis system addresses both parameters in a real-time and physiological manner for reliable, human-relevant results, necessary for a safe transition into clinical stages.

Tags

Hybrid Cell Analysis System Structural Changes Contractile Changes Human IPSC-Derived Cardiomyocytes Preclinical Cardiac Risk Evaluation Cardiac Safety Cardiac Toxicity Drug Candidates Clinical Stages In-vitro Techniques In-vivo Techniques Electrophysiological Parameters Viability Parameters Contractile Properties Physiological Conditions Drug Discovery Higher Throughput System Plate Coating Contraction Plate EHS Gel Coating Solution DPBS With Calcium And Magnesium Membrane Guard
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter