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JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
 

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

Article DOI: 10.3791/64419-v • 12:21 min • September 28th, 2022
September 28th, 2022 •
*1, *2,3, 2, 4, 2,5, 1
1Department of Microbiology and Immunology, University at Buffalo School of Medicine, 2Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 3Graduate Program in Immunology, Tufts Graduate School of Biomedical Sciences, 4Department of Translational Medicine, Lund University, 5Stuart B. Levy Center for the Integrated Management of Antimicrobial Resistance, Tufts University
* These authors contributed equally

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This paper describes a novel mouse model for the transition of pneumococcus from an asymptomatic colonizer to a disease-causing pathogen during viral infection. This model can be readily adapted to study polymicrobial and host-pathogen interactions during the different phases of disease progression and across various hosts.

Tags

Mouse Model Streptococcus Pneumoniae Viral Co-infection Colonizer Pathogen Age-exacerbated Illness Therapeutic Targets Secondary Pneumococcal Pneumonia Aging Susceptibility Host Defects With Age Treatment Options Pneumococcal Biofilm Growing Biofilm H292 Cells Fix Cells With Paraformaldehyde Incubation Conditions Strake Streptococcus Pneumoniae Strain Blood Agar Plate Chemically-defined Media
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