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Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration
 

Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration

Article DOI: 10.3791/64828-v • 05:20 min • March 31st, 2023
March 31st, 2023 •
1,2,3, 1,2, 1,2,3,4,5, 1,2,3,4,5
1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, 2Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, 3Center for Neuromusculoskeletal Restorative Medicine, The Chinese University of Hong Kong, 4Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, The Chinese University of Hong Kong, 5Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong

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This study details procedures for establishing a chronic-like rabbit rotator cuff (RC) injury. Specifically, the injury is created in the subscapularis (SSC) muscle-tendon/myotendinous unit to mimic human RC anatomy and pathophysiology, including severe muscle fatty degeneration (FD). This protocol can be applied to study RC injuries and assess regenerative therapies.

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Rabbit Chronic-like Rotator Cuff Injury Model Fibrosis Muscular Fatty Degeneration Musculature Tendons Strength Retraction Muscle-tendon/myotendinous Unit Shoulder Function RC Repair Outcomes Animal Models Human RC Anatomy And Pathophysiology Tissue Engineering Regenerative Medicine-based Therapeutics Rabbit Subscapularis Model Human Supraspinatus Bone-tendon-muscle Unit Fibrosis And Muscle Fatty Degeneration (FD) Surgical Procedures Isolation Of SSC Coracobrachialis Muscle Full-thickness Transection Silicone-based Penrose Tubing Histologic Evaluation
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