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JoVE Journal Genetics
A Protocol to Evaluate and Quantify Retinal Pigmented Epithelium Pathologies in Mouse Models of Age-Related Macular Degeneration
 

A Protocol to Evaluate and Quantify Retinal Pigmented Epithelium Pathologies in Mouse Models of Age-Related Macular Degeneration

Article DOI: 10.3791/64927-v • 09:24 min • March 10th, 2023
March 10th, 2023 •
1,2, 1, 3, 1,2, 3,4, 1,2
1Department of Medical Genetics, University of Wisconsin-Madison, 2McPherson Eye Research Institute, University of Wisconsin-Madison, 3Department of Ophthalmology, Duke University, 4Department of Cell Biology, Duke University

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Mouse models can be useful tools for investigating the biology of the retinal pigmented epithelium (RPE). It has been established that mice can develop an array of RPE pathologies. Here, we describe a phenotyping protocol to elucidate and quantify RPE pathologies in mice using light, transmission electron, and confocal microscopy.

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Keywords: Retinal Pigmented Epithelium Age-related Macular Degeneration Mouse Model Light Transmission Electron Microscopy Confocal Microscopy Cardiac Perfusion Tissue Fixation Eye Nucleation
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