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Bioengineering

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JoVE Journal Bioengineering
Disruption of the Blood-Spinal Cord Barrier Using Low-Intensity Focused Ultrasound in a Rat Model
 

Disruption of the Blood-Spinal Cord Barrier Using Low-Intensity Focused Ultrasound in a Rat Model

Article DOI: 10.3791/65113-v • 09:03 min • March 10th, 2023
March 10th, 2023 •
1, 1,2,3, 1, 1,3, 1, 1, 1, 1, 1,2,3, 1,3, 2, 1, 1,3, 1,2,3,4,5,6
1Department of Neurosurgery, Johns Hopkins University School of Medicine, 2Department of Biomedical Engineering, Johns Hopkins University, 3HEPIUS Innovation Laboratory, Johns Hopkins University School of Medicine, 4Department of Electrical Engineering and Computer Science, Johns Hopkins University, 5Department of Mechanical Engineering, Johns Hopkins University, 6Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University

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Disruption of the blood-spinal cord barrier (BSCB) can be successfully achieved with the intravenous administration of microbubbles and the application of low-intensity focused ultrasound (LIFU). This protocol details the opening of the BSCB using LIFU in a rodent model, including equipment setup, microbubble injection, target localization, and BSCB disruption visualization.

Tags

Blood-spinal Cord Barrier Disruption Low-intensity Focused Ultrasound LIFU Reversible Neuromodulatory Technology BSCB Disruption Method Rat Model Animal Preparation Microbubble Administration Target Selection And Localization BSCB Disruption Visualization And Confirmation Cost-effective Method Focused Ultrasound Transducer Sonication Parameters Evaluation Drug Delivery At Spinal Cord Immunomodulation Neuromodulation
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