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Medição oxigenação cerebral de sangue baseado em oxigênio-dependente Quenching de fosforescência
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1Optics Division, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology,Massachusetts General Hospital and Harvard Medical School, 2Department of Biochemistry and Biophysics,University of Pennsylvania, 3Neuroprotection Research Laboratory, Departments of Radiology and Neurology,Massachusetts General Hospital and Harvard Medical School, 4Departments of Neurosciences and Radiology,University of California
Chapters
- 00:05Title
- 00:11Introduction
- 00:56Wide Field of View Imaging of Partial Pressure of Oxygen in Cortical Vasculature of a Rat
- 04:55High Resolution Two-photon pO2 Imaging in Cortical Micro Vasculature of a Mouse
- 08:22Conclusion
Nós apresentamos um procedimento experimental para medir a pressão parcial de oxigênio (pO2) na vasculatura cerebral com base em oxigênio-dependente de têmpera de fosforescência. Preparação de animais e procedimentos de imagem foram delineadas para ambos grande campo de visão de imagem CCD-base de pO2 em ratos e dois fótons de imagens de excitação baseada em pO2 em camundongos.
Tags
Cerebral Blood Oxygenation MeasurementOxygen-dependent Quenching Of PhosphorescenceSpatiotemporal CharacteristicsNeuro-metabolic-vascular RelationshipPO2 Measurement ModalitiesLarger Fields Of ViewHigher Spatial ResolutionHigher Temporal ResolutionNormal Brain FunctioningNeurovascular DiseasesStrokeAlzheimer’s DiseaseHead InjuryOptical Imaging ModalitiesHemoglobin AbsorptionVisible And Near Infrared RangeMultispectral MeasurementBlood Oxygenation EstimationPartial Pressure Of Oxygen (pO2)Oxygen-sensitive Dyes
