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Chapters
- 00:05Title
- 01:55Loading of First Bis-Peptide, Deprotection of First Bis-Peptide, and Simultaneous Resin Capping
- 03:43Coupling Tert-butyl Carbamate (Boc)/tert-butyl Ester(tBu)-protected Functionalized Bis-Amino Acid
- 05:21Deprotection of Boc/tBu-protected Functionalized Bis-Amino Acid, Deprotection of Fmoc, and Acylation of the First Bis-Amino Acid
- 06:55Removal of the Boc Group from the Resin Bound Amino Acid and Cleavage from the Resin
- 07:56Assessment Methods
- 09:51Results: Analysis by Liquid Chromatography and Mass Spectroscopy
- 10:36Conclusion
Tags
Solid-phase SynthesisFunctionalized Bis-peptideSafety Catch MethodologyR.B. MerrifieldSolid SupportProtecting GroupsCoupling MethodsBoc-based ProtectionBase/nucleophile Cleavable Resin StrategyFmoc-based ProtectionAcidic Cleavable Resin StrategyPeptidesBoc/tert-butyl Solid-phase Synthesis StrategyBis-peptide LibrariesCleavage StageDiketopiperazine Formation
