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小鼠Spinotrapezius模型来评估的影响小动脉结扎术，微血管功能与重塑

JoVE Journal
Medicine
Author Produced

This content is Free Access.

JoVE Journal Medicine

Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling

Please note that all translations are automatically generated. Click here for the English version.

小鼠Spinotrapezius模型来评估的影响小动脉结扎术，微血管功能与重塑

DOI:

10.3791/50218-v

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16:43 min

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March 03, 2013

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Alexander Michael Guendel*¹, Kyle S. Martin*¹, Joshua Cutts, Patricia L. Foley, Alexander M. Bailey, Feilim Mac Gabhann, Trevor R. Cardinal, Shayn M. Peirce

¹Department of Biomedical Engineering,University of Virginia, ²Department of Biomedical Engineering,California Polytechnic State University, ³Office of Animal Welfare,University of Virginia, ⁴Department of Biomedical Engineering & Institute for Computational Medicine,Johns Hopkins University

Chapters

00:01Title
01:34Introduction
03:48Surgical Instruments
04:02Mouse Preparation
04:47Ligation Procedure
09:25Intravital Microscopy and Functional Vasodilation
12:04Tissue Harvest
14:24Representative Results
16:15Conclusion

Summary

Automatic Translation

我们展示了一种新的动脉导管结扎术模型在小鼠spinotrapezius的肌肉，包括一步一步的程序和所需的仪器的描述。我们描述了外科手术和相关结果的测量，使用活体和共聚焦显微镜的血管网重构和功能的血管扩张有关。

Tags

Murine Spinotrapezius Arteriolar Ligation Microvascular Function Microvascular Remodeling Intravital Microscopy Confocal Microscopy Skeletal Muscle Ischemia Revascularization Functional Vasodilation Immunostaining

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