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一<em>线虫</em>研究Amylopathy模型系统
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Neuroscience
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JoVE Journal Neuroscience
A Caenorhabditis elegans Model System for Amylopathy Study
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一<em>线虫</em>研究Amylopathy模型系统

DOI:
10.3791/50435-v

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10:33 min

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May 17, 2013

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1Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School,University of Medicine and Dentistry of New Jersey

Chapters

  • 00:05Title
  • 01:25Transformation of Transgenic Worms
  • 04:24Age-synchronization
  • 05:39Chemotaxis Assay
  • 06:44Primary Embryonic Cell Culture
  • 08:51The Effects of Human Aβ42 Oligomer on Neuronal Function
  • 10:11Conclusion

Summary

Automatic Translation

Automatic Translation

我们描述的方法来研究蠕虫amylopathies方面<em> C。线虫</em>。我们将展示如何构建表达Aβ的蠕虫<sub> 42</sub>在神经元和如何测试其功能行为分析。进一步的研究表明如何获取药理试验，可用于主培养的神经元。

Tags

Keywords: Caenorhabditis ElegansAmylopathyAlzheimer’s DiseaseAmyloid BetaNeurodegenerationTransgenicBehavioral AssaysNeuronal Cultures

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