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JoVE Journal Bioengineering
Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
 

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Article DOI: 10.3791/50638-v • 18:57 min • October 17th, 2013
October 17th, 2013 •
1, 1,2
1Fischell Department of Bioengineering, University of Maryland, 2Institute for Bioscience and Biotechnology Research, University of Maryland

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Summary
Automatic Translation

Many therapeutic applications require safe and efficient transport of drug carriers and their cargoes across cellular barriers in the body. This article describes an adaptation of established methods to evaluate the rate and mechanism of transport of drug nanocarriers (NCs) across cellular barriers, such as the gastrointestinal (GI) epithelium.

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Keywords: Drug Delivery Systems Nanocarriers Cellular Barriers Paracellular Transport Transcellular Transport Transepithelial Electrical Resistance Transwell Endocytosis Transcytosis Radioisotope Tracing
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