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Reproducable Paraplegia by Thoracic Aortic Occlusion in a Murine Model of Spinal Cord Ischemia-reperfusion
JoVE Journal
Medicine
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JoVE Journal Medicine
Reproducable Paraplegia by Thoracic Aortic Occlusion in a Murine Model of Spinal Cord Ischemia-reperfusion
DOI:

05:59 min

March 03, 2014

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Chapters

  • 00:05Title
  • 02:06Rectal Probe Doppler Placement
  • 02:54Dissection of Aortic Arch/Subclavian Artery
  • 04:59Representative Thoracic Aortic Occlusion-induced Paraplegia Results
  • 05:38Conclusion

Summary

Automatic Translation

The lack of mechanistic understanding of spinal cord ischemia-reperfusion injury has hindered further adjuncts to prevent paraplegia following high risk aortic operations. Thus, the development of animal models is imperative. This manuscript demonstrates reproducible lower extremity paralysis following thoracic aortic occlusion in a murine model.

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