Journal
/
Immunology and Infection
/
A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
JoVE Journal
Immunology and Infection
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Immunology and Infection
A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

DOI:
10.3791/51556-v

•

09:52 min

•

August 08, 2014

•

, , , , , , ,
1Department of Medicine, Section of Infectious Disease,Boston University School of Medicine, 2Department of Biophysics,Boston University School of Medicine

Chapters

  • 00:05Title
  • 01:55Growth and Cultivation of Bacteria
  • 03:25MRI Data Acquisition
  • 05:00Aorta Pinning
  • 06:07Lipid Staining and Lesion Quantification
  • 07:27Results: Pathogen-induced Chronic Inflammation at Local and Systemic Sites
  • 08:52Conclusion

Summary

Automatic Translation

Automatic Translation

Animal models have proven to be invaluable tools in defining host and pathogen specific mechanisms that contribute to the development of chronic inflammation. Here we describe a mouse model of oral infection with the human pathogen Porphyromonas gingivalis and detail methodologies to assess the progression of inflammation at local and systemic sites.

Tags

Mouse ModelChronic InflammationPathogen-inducedPorphyromonas GingivalisPeriodontal DiseaseAtherosclerosisInflammatory ResponseAlveolar BoneVascular EndotheliumInflammatory MediatorsTransgenic MiceBacterial MutantsTherapeutic Strategies

Article

Embed

ADD TO PLAYLIST

Usage Statistics

Related Videos

Trichuris muris Infection: A Model of Type 2 Immunity and Inflammation in the Gut

Using the BLT Humanized Mouse as a Stem Cell based Gene Therapy Tumor Model

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

In vitro Coculture Assay to Assess Pathogen Induced Neutrophil Trans-epithelial Migration

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Co-immunoprecipitation of the Mouse Mx1 Protein with the Influenza A Virus Nucleoprotein

An Optimized Method for Isolating and Expanding Invariant Natural Killer T Cells from Mouse Spleen

Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Read Article