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Oxygen-Glucose Deprivation and Reoxygenation as an In Vitro Ischemia-Reperfusion Injury Model for Studying Blood-Brain Barrier Dysfunction
 

Oxygen-Glucose Deprivation and Reoxygenation as an In Vitro Ischemia-Reperfusion Injury Model for Studying Blood-Brain Barrier Dysfunction

Article DOI: 10.3791/52699-v • 08:56 min • May 7th, 2015
May 7th, 2015 •
1,2, 2, 1,2, 1,2
1Department of Surgery, Texas A&M University Health Science Center College of Medicine, 2Department of Surgery, Baylor Scott & White Health

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Summary
Automatic Translation

Ischemia-Reperfusion (IR) injury is associated with a high rate of morbidity and mortality. The goal of the in vitro model of oxygen-glucose deprivation and reoxygenation (OGD-R) described here is to assess the effects of ischemia reperfusion injury on a variety of cells, particularly in blood-brain barrier (BBB) endothelial cells.

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Keywords: Oxygen-glucose Deprivation Reoxygenation Ischemia-reperfusion Injury Blood-brain Barrier Tight Junctions Endothelial Cells In Vitro Model Stroke Oxidative Stress Inflammatory Response
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