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Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
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JoVE Journal Medicine
Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols

Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols

DOI:
10.3791/53902-v

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15:04 min

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May 20, 2016

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,
1Department of Mechanical Engineering,California Baptist University, 2School of Engineering and Technology,Central Michigan University

Chapters

  • 00:05Title
  • 01:06Image-Based Nasal Airway Preparation
  • 04:32Passive Control of Particles: Intubation
  • 07:37Active Control of Particles: Magnetophoretic Guidance
  • 09:57Testing of 2D/3D Nose Models
  • 12:57Results: Alternative Nasal Devices Through Intubation and Magnetophoretic Guidance Prove Superior to Conventional Methods
  • 14:01Conclusion

Summary

Automatic Translation

Automatic Translation

This manuscript reviews the modeling and simulations of different protocols to deliver medications to the olfactory region in image-based nasal airway models. Multiple software modules are used to develop the anatomically accurate nose model, generate computational mesh, simulate nasal airflows, and predict particle deposition at the olfactory region.

Tags

Keywords: Olfactory Drug DeliveryNasal Airway ModelingPassive And Active ControlsPharmaceutical AerosolsNose-to-brain Drug DeliveryMRI-based 3D ModelingComputational Fluid DynamicsOlfactory TargetingNeurological Drug DeliveryBrain Tumor Therapy

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