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Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
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Medicine
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JoVE Journal Medicine
Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

DOI:
10.3791/53913-v

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07:48 min

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May 16, 2016

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, , , ,
1Centre for Clinical Pharmacology, Division of Medicine,University College London

Chapters

  • 00:05Title
  • 01:19Endotoxin Challenge Participant Preparation
  • 03:35Endotoxin Administration and Monitoring
  • 05:40Results: Representative Cellular and Humoral Responses and Symptom Profile after CCRE Challenge
  • 06:36Conclusion

Summary

Automatic Translation

Automatic Translation

Intravenous administration of endotoxin reliably elicits dose-dependent physiological and immunological alterations consistent with several pathological states. This reductionist approach permits the investigation, modeling and experimental modification of systemic inflammation and its downstream effects in man.

Tags

Keywords: Intravenous Endotoxin ChallengeSystemic InflammationExperimental PlatformCritical IllnessSepsisAseptic TechniqueClinical ProcedureHealth ScreeningIntravenous CannulaResuscitation Equipment

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