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持续静脉注射是精氨酸加压素受体拮抗剂考尼伐坦的选择治疗途径小鼠来研究中风诱发脑水肿
JoVE Journal
Medicine
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JoVE Journal Medicine
Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema
DOI:

08:44 min

September 01, 2016

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Chapters

  • 00:05Title
  • 00:48In Vivo Stroke Induction
  • 03:06Neurological Deficit Scoring (NDS) and Filament Removal
  • 04:14Intravenous Catheter Jugular Vein Installation for Continuous 48 Hr Treatment
  • 06:28Results: Representative Effects of Continuous I.V. or I.P. Conivaptan Treatment on Stroke-evoked Brain Edema
  • 07:18Conclusion

Summary

Automatic Translation

Our studies have revealed that the beneficial effects of conivaptan are dependent on the method of delivery after experimental stroke in mice. We have developed a research protocol for delivery of the receptor blocker via IV catheter on stroke-evoked brain edema formation in mice.

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