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Chapters
- 00:05Title
- 00:54Administration of Test Substance and Preparation of FITC-Dextran
- 02:42Preparation of the Left Jugular Vein and Injection of FITC-Dextran
- 03:51Positioning the Right Ear for Intravital Fluorescence Microscopy
- 05:24Intravital Fluorescence Microscopy and Thrombus Induction of the Right Ear
- 07:01Venular Thrombus Formation after Single Cannabinoid Treatment and Cyclooxygenase Inhibition
- 08:03Conclusion
The ear model of the hairless SKH1-Hrhr mouse enables intravital fluorescence microscopy of microcirculation and phototoxic thrombus induction without prior surgical preparation in the examined microvascular bed. Therefore, the ear of the hairless mouse is an excellent in vivo model to study the complex interactions during microvascular thrombus formation, thrombus evolution, and thrombolysis.
