Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Chiara Arienti; Sara Pignatta; Michele Zanoni; Michela Cortesi; Alice Zamagni; Filippo Piccinini; Anna Tesei

doi:10.3791/56583

Journal

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Cancer Research

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寻找获得性抗靶治疗的驱动途径: 耐药亚克隆生成与基因击倒敏感性恢复

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JoVE Journal Cancer Research

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Please note that all translations are automatically generated. Click here for the English version.

寻找获得性抗靶治疗的驱动途径: 耐药亚克隆生成与基因击倒敏感性恢复

DOI:

10.3791/56583-v

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08:59 min

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December 11, 2017

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Chiara Arienti, Sara Pignatta, Michele Zanoni, Michela Cortesi, Alice Zamagni, Filippo Piccinini, Anna Tesei

¹Biosciences Laboratory,Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, ²Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS

Chapters

00:05Title
01:39Generation of Targeted Therapy Resistant Subclones
04:03Restoring Target-therapy Inhibitor Sensitivity by Candidate R-gene Knock-down
06:31Results: Drug Resistant Subclone Generation and Sensitivity Restoration
08:01Conclusion

Summary

Automatic Translation

这是一个时间和经济高效的体外协议, 研究对靶向治疗剂的后天抗性机制, 这是癌症管理中极不满足的医疗需求。

寻找获得性抗靶治疗的驱动途径: 耐药亚克隆生成与基因击倒敏感性恢复

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