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PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
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JoVE Journal Cancer Research
PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

DOI:
10.3791/56601-v

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10:48 min

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December 28, 2017

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, , , ,
1Department of Nuclear Medicine,Ghent University Hospital, 2IBiTech-MEDISIP, Department of Electronics and Information Systems,Ghent University, 3Department of Radiation Oncology,Ghent University Hospital

Chapters

  • 00:05Title
  • 00:53F98 Glioblastoma (GB) Rat Cell Model
  • 02:12Tumor Growth Confirmation
  • 03:26Multimodality Imaging for Target Volume Selection
  • 05:18Radiation Therapy (RT) Treatment Planning
  • 09:07Results: Representative Selected MRI and PET-guided Isocenters for Irradiation
  • 10:11Conclusion

Summary

Automatic Translation

Automatic Translation

In the past, small animal irradiation was usually performed without the ability to target a well-delineated tumor volume. The goal was to mimic the treatment of human glioblastoma in rats. Using a small animal irradiation platform, we performed MRI-guided 3D conformal irradiation with PET-based sub-volume boosting in a preclinical setting.

Tags

PETMRIGlioblastomaRat ModelMicro-irradiatorImage-guidedConformal IrradiationRadiation TherapyTumor VolumeCancer BiologyStereotacticInoculationMRI ScanContrast Agent

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