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JoVE Journal Behavior
Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm
 

Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm

Article DOI: 10.3791/56983-v • 08:29 min • June 7th, 2018
June 7th, 2018 •
1, 1, 1, 1
1Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universitat de València

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Summary
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This protocol describes the Conditioned Place Preference (CPP) as a model of relapse. This procedure permits the measurement of relapse in laboratory animals, considering the impact of drug-associated environmental cues as craving and relapse in abstaining addicts is currently the focus of drug-abuse treatment programs.

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Keywords: Drug-seeking Reinstatement Conditioned Place Preference CPP Drug Addiction Relapse Environmental Cues Stress Incentive Motivational Value Ethology Social Defeat Habituation Cocaine Mouse
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