Journal
/
Biology
/
Implantation of Electrospun Vascular Grafts with Optimized Structure in a Rat Model
JoVE Journal
Biology
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Biology
Implantation of Electrospun Vascular Grafts with Optimized Structure in a Rat Model

Implantation of Electrospun Vascular Grafts with Optimized Structure in a Rat Model

DOI:
10.3791/57340-v

•

08:46 min

•

June 27, 2018

•

, , , , ,
1State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials (Ministry of Education), College of Life Sciences,Nankai University

Chapters

  • 00:04Title
  • 00:59Fabrication of Electrospun PCL Grafts
  • 02:54Electrospun PCL Graft Characterization
  • 03:57Rat Abdominal Aorta Implantation Model
  • 07:11Results: Regenerated Tissue is Supported by PCL Grafts
  • 08:16Conclusion

Summary

Automatic Translation

Automatic Translation

Here, we present a modified electrospinning method to fabricate PCL vascular grafts with thick fibers and large pores, and describe a protocol to evaluate the in vivo performance in a rat model of abdominal aorta replacement.

Tags

Electrospun Vascular GraftPolycaprolactoneFiber DiameterPore SizeTensile TestingSEM ImagingRat Abdominal Aorta ImplantationVascular Regeneration

Article

Embed

ADD TO PLAYLIST

Usage Statistics

Related Videos

The Structure of Skilled Forelimb Reaching in the Rat: A Movement Rating Scale

Implantation of Engineered Tissue in the Rat Heart

Whole-mount Immunohistochemical Analysis for Embryonic Limb Skin Vasculature: a Model System to Study Vascular Branching Morphogenesis in Embryo

Rat Mesentery Exteriorization: A Model for Investigating the Cellular Dynamics Involved in Angiogenesis

Functional Reconstitution and Channel Activity Measurements of Purified Wildtype and Mutant CFTR Protein

Evaluating Vascular Hyperpermeability-inducing Agents in the Skin with the Miles Assay

Optimized Scratch Assay for In Vitro Testing of Cell Migration with an Automated Optical Camera

Mass Spectrometry Analysis to Identify Ubiquitylation of EYFP-tagged CENP-A (EYFP-CENP-A)

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Isolation of Primary Rat Hepatocytes with Multiparameter Perfusion Control

Read Article