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炎症敏感晚期缺氧缺血性脑损伤的Ferret模型

JoVE Journal
Neuroscience

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JoVE Journal Neuroscience

A Ferret Model of Inflammation-sensitized Late Preterm Hypoxic-ischemic Brain Injury

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炎症敏感晚期缺氧缺血性脑损伤的Ferret模型

DOI:

10.3791/60131-v

•

07:36 min

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November 19, 2019

•

Thomas Wood, Daniel Moralejo, Kylie Corry, Cole Fisher, Jessica M. Snyder, Vivienne Acuna, Alair Holden-Hunt, Simar Virk, Olivia White, Janessa Law, Pratik Parikh, Sandra E. Juul

¹Division of Neonatology, Department of Pediatrics,University of Washington, ²Department of Comparative Medicine,University of Washington

Chapters

00:04Title
00:44Surgical Preparation
01:34Bilateral Carotid Artery Ligation
02:44Sequential Hypoxia, Hyperoxia, and Hypoxia
04:02Right Carotid Artery Ligation Reversal and Recovery and Temperature Management
04:40Ex Vivo Brain Measurement
05:33Results: Representative Morphological and Functional Injury Effects
07:00Conclusion

Summary

Automatic Translation

该方法描述了P17雪铁龙中发炎意识低氧缺血和高氧脑损伤，以模拟一些晚期早产儿经历的长期炎症和氧化性脑损伤之间的复杂相互作用。

Tags

Ferret Model Inflammation-sensitized Late Preterm Hypoxic-ischemic Brain Injury LPS Carotid Artery Ligation Hypoxia Hyperoxia Brain Injury

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