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JoVE Journal Developmental Biology
Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
 

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Article DOI: 10.3791/60455-v • 10:25 min • December 12th, 2019
December 12th, 2019 •
1, 1,2,3,4
1Institute for Frontier Life and Medical Sciences, Kyoto University, 2Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, 3Kyoto University Graduate School of Medicine, 4Kyoto University Graduate School of Biostudies

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Summary
Automatic Translation

Neural stem/progenitor cells exhibit various expression dynamics of Notch signaling components that lead to different outcomes of cellular events. Such dynamic expression can be revealed by real-time monitoring, not by static analysis, using a highly sensitive bioluminescence imaging system that enables visualization of rapid changes in gene expressions.

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Keywords: Bioluminescence Imaging Notch Signaling Neurogenesis Neural Progenitor Cells Dll1 Reporter In Vivo Imaging Real-time Gene Expression Cell Proliferation Cell Differentiation Embryonic Development
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