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A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
 

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Article DOI: 10.3791/61058-v • 08:21 min • October 26th, 2020
October 26th, 2020 •
1, 1, 1, 1
1Department of Medicine/Clinical Pharmacology Division, Vanderbilt University Medical Center

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Summary
Automatic Translation

A modified 2 kidney 1 clip (2K1C) Goldblatt mouse model was developed using polyurethane tubing to initiate renal artery stenosis, inducing an increase in renin expression and kidney injury. Here, we describe a detailed procedure of preparing and placing the cuff onto the renal artery to generate a reproducible and consistent 2K1C mouse model.

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Keywords: 2K1C Mouse Model Renal Artery Stenosis Renin Regulation Renal Vascular Hypertension Polyurethane Tubing Renal Artery Constriction Surgical Procedure Mouse Surgery Anesthesia Renal Artery Isolation Renal Nerve Isolation
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