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Journal / Neuroscience / Implantation of Osmotic Pumps and Induction of…
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JoVE Journal Neuroscience
Implantation of Osmotic Pumps and Induction of Stress to Establish a Symptomatic, Pharmacological Mouse Model for DYT/PARK-ATP1A3 Dystonia
 

Implantation of Osmotic Pumps and Induction of Stress to Establish a Symptomatic, Pharmacological Mouse Model for DYT/PARK-ATP1A3 Dystonia

Article DOI: 10.3791/61635-v • 10:41 min • September 12th, 2020
September 12th, 2020 •
1, 1, 1, 1
1Department of Neurology, University Hospital of Würzburg

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We provide a protocol to generate a pharmacological DYT/PARK-ATP1A3 dystonia mouse model via implantation of cannulas into basal ganglia and cerebellum connected to osmotic pumps. We describe the induction of dystonia-like movements via application of a motor challenge and the characterization of the phenotype via behavioral scoring systems.

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Keywords: Osmotic Pumps Brain Cannulas Pharmacological Mouse Model DYT/PARK-ATP1A3 Dystonia Motor Stress Gene-environment Interactions Movement Disorders Stereotactic Surgery Basal Ganglia Cerebellum
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