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Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
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JoVE Journal Chemistry
Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach

DOI:
10.3791/61944-v

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14:11 min

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June 10, 2021

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, ,
1Department of Physical and Life Sciences,Nevada State College, 2Department of Humanities,Nevada State College

Chapters

  • 00:00Introduction
  • 04:18Experimental Procedure
  • 06:38Vacuum Filtration Purification Procedure
  • 08:20Flash Column Chromotography Purification Procedure
  • 10:16Spectroscopic Analysis of Dipyrrinone Analogs
  • 10:42Results
  • 11:57Conclusion

Summary

Automatic Translation

Automatic Translation

The Claisen-Schmidt condensation reaction is an important methodology for the generation of methine-bridged conjugated bicyclic aromatic compounds. Through utilizing a base-mediated variant of the aldol reaction, a range of fluorescent and/or biologically relevant molecules can be accessed through a generally inexpensive and operationally simple synthetic approach.

Tags

Keywords: Claisen-Schmidt CondensationEnolateAromatic AldehydeChalconesFlavanonesMethine-bridged CompoundsDipyrrinonesFluorescenceXanthoglowsUV-visible AbsorptionIsomerization

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