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Gerenciamento Avançado do Ritmo Cardíaco Aplicando Fotoestimulação Optogenética Multi-Site em Corações Murinos
 
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Gerenciamento Avançado do Ritmo Cardíaco Aplicando Fotoestimulação Optogenética Multi-Site em Corações Murinos

Article DOI: 10.3791/62335-v • 08:43 min • August 26th, 2021
August 26th, 2021 •
*1,2, *1, 8,9, 1,3,4,6, 8,9, 1,5,6,7
1Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, 2Research Electronics Department, Max Planck Institute for Dynamics and Self-Organization, 3Department of Pharmacology and Toxicology, University Medical Center Goettingen, 4Institute for Nonlinear Dynamics, Georg-August-University Goettingen, 5Department of Cardiology and Pneumology, University Medical Center Goettingen, 6German Center for Cardiovascular Research, DZHK e.V., partner site Goettingen, 7Laboratory Animal Science Unit, German Primate Center Leibniz Institute for Primate Research, 8Department of Microsystems Engineering (IMTEK), University of Freiburg, 9Cluster of Excellence BrainLinks-BrainTools, University of Freiburg
* These authors contributed equally

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Este trabalho relata um método de controle do ritmo cardíaco de corações murinos intactos de camundongos transgênicos com canalrodopsina-2 (ChR2) utilizando fotoestimulação local com matriz micro-LED e mapeamento óptico simultâneo do potencial de membrana epicárdica.

Tags

Medicina Edição 174 optogenética cardíaca mapeamento óptico LED DI-4-ANBDQPQ Blebbistatina channelrhodopsin-2 ChR2
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