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Journal / Medicine / Murin Kalplerde Optogenetik Çok Bölgeli…
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Murin Kalplerde Optogenetik Çok Bölgeli Fotostimülasyon Uygulayarak İleri Kardiyak Ritim Yönetimi
 
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Murin Kalplerde Optogenetik Çok Bölgeli Fotostimülasyon Uygulayarak İleri Kardiyak Ritim Yönetimi

Article DOI: 10.3791/62335-v • 08:43 min • August 26th, 2021
August 26th, 2021 •
*1,2, *1, 8,9, 1,3,4,6, 8,9, 1,5,6,7
1Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, 2Research Electronics Department, Max Planck Institute for Dynamics and Self-Organization, 3Department of Pharmacology and Toxicology, University Medical Center Goettingen, 4Institute for Nonlinear Dynamics, Georg-August-University Goettingen, 5Department of Cardiology and Pneumology, University Medical Center Goettingen, 6German Center for Cardiovascular Research, DZHK e.V., partner site Goettingen, 7Laboratory Animal Science Unit, German Primate Center Leibniz Institute for Primate Research, 8Department of Microsystems Engineering (IMTEK), University of Freiburg, 9Cluster of Excellence BrainLinks-BrainTools, University of Freiburg
* These authors contributed equally

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Bu çalışma, transgenik channelrhodopsin-2 (ChR2) farelerinin bozulmamış murin kalplerinin kardiyak ritmini, bir mikro-LED dizisi ile lokal fotostimülasyon ve epikardiyal membran potansiyelinin eşzamanlı optik haritalamasını kullanarak kontrol etmek için bir yöntem bildirmektedir.

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Tıp Sayı 174 kardiyak optogenetik optik haritalama LED DI-4-ANBDQPQ Blebbistatin channelrhodopsin-2 ChR2
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