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癫痫小鼠模型中热诱发癫痫发作的行为筛查

JoVE Journal
Neuroscience

This content is Free Access.

JoVE Journal Neuroscience

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

Please note that all translations are automatically generated. Click here for the English version.

癫痫小鼠模型中热诱发癫痫发作的行为筛查

DOI:

10.3791/62846-v

•

06:58 min

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July 12, 2021

•

Antara Das, Martin A. Smith, Diane K. O’Dowd

¹Department of Developmental and Cell Biology,University of California, ²Department of Anatomy and Neurobiology,University of California

Chapters

00:04Introduction
01:06Preparation for the Heat-Induced Seizure Assay
02:36Heat-Induced Seizure Assay
04:36Results: Screening for Occurrence of Heat-Induced Seizures in Mice with the Different Genetic Backgrounds
06:17Conclusion

Summary

Automatic Translation

该方法的目标是在小鼠模型中筛查热疗或热诱发的癫痫发作。该协议描述了使用定制的腔室，连续监测体温，以确定体温升高是否会导致癫痫发作。

Tags

Keywords: Heat-induced Seizures GEFS+ Mutations Febrile Seizures Digital Temperature Controller Heating Box Body Temperature Potential Therapies Rectal Temperature Probe Anesthesia Screening Assay Body Weight Recovery Cage Core Body Temperature Heat Chamber Temperature Gradient

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