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Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
 

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging

Article DOI: 10.3791/63264-v • 11:07 min • November 24th, 2021
November 24th, 2021 •
1, 1, 1, 1
1Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School

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Summary
Automatic Translation

A coherent Raman scattering imaging methodology to visualize and quantify pharmaceutical compounds within the skin is described. This paper describes skin tissue preparation (human and mouse) and topical formulation application, image acquisition to quantify spatiotemporal concentration profiles, and preliminary pharmacokinetic analysis to assess topical drug delivery.

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Keywords: Coherent Raman Scattering Imaging Topical Drug Quantification Cutaneous Pharmacokinetics Tissue Preparation Nude Mouse Ear Skin Human Skin Subcutaneous Fat Removal Lipid Imaging Drug Quantification
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