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使用相干拉曼散射成像对皮肤内的药物化合物进行可视化和定量
JoVE Journal
Medicine
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JoVE Journal Medicine
Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
DOI:

11:07 min

November 24, 2021

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Chapters

  • 00:04Introduction
  • 00:56Preparation of Nude Mouse Ear Skin Tissue
  • 01:46Preparation of Human Skin Tissue
  • 02:26Lipid Imaging and Application of Topical Formulation
  • 03:11Experimental Setup for Drug Quantification and Data Analysis
  • 08:53Results: Analysis of the Skin for Tissue Movement and Concentration of Drug at Different Timepoints
  • 10:28Conclusion

Summary

Automatic Translation

本文介绍了一种相干拉曼散射成像方法,用于可视化和量化皮肤内的药物化合物。本文介绍了皮肤组织制剂(人和小鼠)和局部制剂的应用,用于量化时空浓度曲线的图像采集,以及用于评估局部药物递送的初步药代动力学分析。

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