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用于胶质母细胞瘤脉冲电场治疗的柔性有机电子器件

JoVE Journal
Cancer Research

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JoVE Journal Cancer Research

Flexible Organic Electronic Devices for Pulsed Electric Field Therapy of Glioblastoma

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用于胶质母细胞瘤脉冲电场治疗的柔性有机电子器件

DOI:

10.3791/63527-v

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11:02 min

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August 09, 2022

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Marie C. Lefevre, Attila Kaszas, Gerwin Dijk², Martin Baca, Olivier Baudino, Bastien Marchiori, Loig Kergoat, David Moreau, Franck Debarbieux^4,5, Rodney P. O’Connor

¹Centre CMP, Bioelectronics Department,Mines Saint-Etienne, ²Panaxium SAS, ³Institut Universitaire de France, ⁴Institut des Neurosciences de la Timone (UMR7289), CNRS,Aix-Marseille Université, ⁵Centre Européen de Recherche en Imagerie Médicale,Aix-Marseille Université

Chapters

00:05Introduction
00:57Flexible Device Microfabrication
03:573D Models for Spheroid Culture
05:063D Models for the In Ovo Culture
06:02Implantation of Flexible Interdigitated Electrodes for the In Vivo Model
08:24Results: Characterization of Flexible Interdigitated Electrodes and Implementation in Brain Tumor Models
10:11Conclusion

Summary

Automatic Translation

这项工作描述了用于在3D脑肿瘤模型中实现的柔性指间电极的开发，即体外培养，卵子模型和体内小鼠模型。所提出的方法可用于评估不同复杂程度的脉冲电场对肿瘤的影响。

Tags

Keywords: Flexible Electronics Pulsed Electric Field Therapy Glioblastoma Tumor Microenvironment Precision Medicine Microfabrication Parylene C Photoresist Interdigitated Electrode Chromium Gold Thermal Evaporation

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