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Journal
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Bioengineering
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创建膝关节芯片,用于关节疾病建模和药物测试
JoVE Journal
Bioengineering
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JoVE Journal
Bioengineering
Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs
Please note that all translations are automatically generated.
Click here for the English version.
创建膝关节芯片,用于关节疾病建模和药物测试
DOI:
10.3791/64186-v
•
12:44 min
•
January 27, 2023
•
Meagan J. Makarcyzk
2
,
Zhong Alan Li
3
,
Ilhan Yu
,
Haruyo Yagi
,
Xiurui Zhang
,
Lauren Yocum
,
Eileen Li
,
Madalyn R. Fritch
,
Qi Gao
,
Bruce A. Bunnell
,
Stuart B. Goodman
6
,
Rocky S. Tuan
8
,
Peter G. Alexander
7
,
Hang Lin
2,7
1
Department of Orthopaedic Surgery
,
University of Pittsburgh School of Medicine
,
2
Department of Bioengineering
,
University of Pittsburgh Swanson School of Engineering
,
3
Department of Neurobiology
,
University of Pittsburgh School of Medicine
,
4
Department of Orthopaedic Surgery
,
Stanford University
,
5
Department of Microbiology, Immunology, and Genetics
,
University of North Texas Health Science Center
,
6
Department of Bioengineering
,
Stanford University
,
7
McGowan Institute for Regenerative Medicine
,
University of Pittsburgh School of Medicine
,
8
The Chinese University of Hong Kong
Chapters
00:05
Introduction
00:43
Engineering the Tissue Components
05:49
Establishing the Minijoint Chip
08:13
Individual Tissue Collection
09:35
Results: Establishment of a Miniature Synovial Joint-Mimicking Microphysiological System
12:07
Conclusion
Summary
Automatic Translation
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Automatic Translation
我们提供了从人间充质干细胞生成四种类型的组织的详细方法,这些组织用于概括人膝关节中的软骨、骨骼、脂肪垫和滑膜。这四个组织被集成到一个定制的生物反应器中,并通过微流体连接,从而产生一个膝关节芯片。
Tags
Keywords: Knee Joint-on-a-chip
Microphysiological System
Osteoarthritis
Disease Modifying Osteoarthritis Drugs
GelMA
Methacrylated Gelatin
Mesenchymal Stem Cells
3D Printed Bioreactor
Preclinical Model
Drug Testing
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