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创建膝关节芯片,用于关节疾病建模和药物测试
JoVE Journal
Bioengineering
Author Produced
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JoVE Journal Bioengineering
Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs
DOI:

12:44 min

January 27, 2023

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Chapters

  • 00:05Introduction
  • 00:43Engineering the Tissue Components
  • 05:49Establishing the Minijoint Chip
  • 08:13Individual Tissue Collection
  • 09:35Results: Establishment of a Miniature Synovial Joint-Mimicking Microphysiological System
  • 12:07Conclusion

Summary

Automatic Translation

我们提供了从人间充质干细胞生成四种类型的组织的详细方法,这些组织用于概括人膝关节中的软骨、骨骼、脂肪垫和滑膜。这四个组织被集成到一个定制的生物反应器中,并通过微流体连接,从而产生一个膝关节芯片。

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