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Opprettelse av et kneledd på en brikke for modellering av leddsykdommer og testing av medisiner
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1Department of Orthopaedic Surgery,University of Pittsburgh School of Medicine, 2Department of Bioengineering,University of Pittsburgh Swanson School of Engineering, 3Department of Neurobiology,University of Pittsburgh School of Medicine, 4Department of Orthopaedic Surgery,Stanford University, 5Department of Microbiology, Immunology, and Genetics,University of North Texas Health Science Center, 6Department of Bioengineering,Stanford University, 7McGowan Institute for Regenerative Medicine,University of Pittsburgh School of Medicine, 8The Chinese University of Hong Kong
Chapters
- 00:05Introduction
- 00:43Engineering the Tissue Components
- 05:49Establishing the Minijoint Chip
- 08:13Individual Tissue Collection
- 09:35Results: Establishment of a Miniature Synovial Joint-Mimicking Microphysiological System
- 12:07Conclusion
Vi tilbyr detaljerte metoder for å generere fire typer vev fra humane mesenkymale stamceller, som brukes til å rekapitulere brusk, bein, fettpute og synovium i det menneskelige kneleddet. Disse fire vevene er integrert i en tilpasset bioreaktor og koblet sammen gjennom mikrofluidikk, og genererer dermed et kneledd på en brikke.
