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通过分子建模方法探索半胱天冬酶突变和翻译后修饰
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Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches
Please note that all translations are automatically generated.
Click here for the English version.
通过分子建模方法探索半胱天冬酶突变和翻译后修饰
DOI:
10.3791/64206-v
•
05:56 min
•
October 13, 2022
•
Dmitry K. Nilov
,
Alexey V. Zamaraev
,
Boris Zhivotovsky
3
,
Gelina S. Kopeina
1
Belozersky Institute of Physicochemical Biology
,
Lomonosov Moscow State University
,
2
Faculty of Medicine
,
Lomonosov Moscow State University
,
3
Division of Toxicology, Institute of Environmental Medicine
,
Karolinska Institute
Chapters
00:04
Introduction
01:05
System Preparation
02:25
Energy Minimization
03:16
Heating, Equilibration, and Production Dynamics
04:36
Results: Biomolecular Simulation of the Wild-Type Caspase and its Mutant Form
05:27
Conclusion
Summary
Automatic Translation
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Automatic Translation
本协议使用生物分子模拟包,并描述了用于模拟野生型半胱天冬酶及其突变形式的分子动力学(MD)方法。MD方法允许评估半胱天冬酶结构的动态演变以及突变或翻译后修饰的潜在影响。
Tags
Caspase
Post-translational Modification
Molecular Modeling
Molecular Dynamics
Protein Structure
Cell Death
Amber
Energy Minimization
Molecular Mechanics
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