Alessandro Lugli Institute of Pathology University of Bern Biography Publications Institution JoVE Articles Alessandro Lugli has not added a biography. If you are Alessandro Lugli and would like to personalize this page please email our Author Liaison for assistance. Publications Tumor Budding in Upper Gastrointestinal Carcinomas Frontiers in Oncology. 2014 | Pubmed ID: 25177546 Evaluation of Colon Cancer Histomorphology: a Comparison Between Formalin and PAXgene Tissue Fixation by an International Ring Trial Virchows Archiv : an International Journal of Pathology. Aug, 2014 | Pubmed ID: 25085759 Investigation of IL-23 (p19, P40) and IL-23R Identifies Nuclear Expression of IL-23 P19 As a Favorable Prognostic Factor in Colorectal Cancer: a Retrospective Multicenter Study of 675 Patients Oncotarget. Jul, 2014 | Pubmed ID: 25015728 Defined Morphological Criteria Allow Reliable Diagnosis of Colorectal Serrated Polyps and Predict Polyp Genetics Virchows Archiv : an International Journal of Pathology. Jun, 2014 | Pubmed ID: 24728704 CD8/CD45RO T-cell Infiltration in Endoscopic Biopsies of Colorectal Cancer Predicts Nodal Metastasis and Survival Journal of Translational Medicine. 2014 | Pubmed ID: 24679169 The Tumor Border Configuration of Colorectal Cancer As a Histomorphological Prognostic Indicator Frontiers in Oncology. 2014 | Pubmed ID: 24600585 HLA Class II Antigen Expression in Colorectal Carcinoma Tumors As a Favorable Prognostic Marker Neoplasia (New York, N.Y.). Jan, 2014 | Pubmed ID: 24563618 Possible Role of Cdx2 in the Serrated Pathway of Colorectal Cancer Characterized by BRAF Mutation, High-level CpG Island Methylator Phenotype and Mismatch Repair-deficiency International Journal of Cancer. Journal International Du Cancer. May, 2014 | Pubmed ID: 24166180 Towards the Introduction of the 'Immunoscore' in the Classification of Malignant Tumours The Journal of Pathology. Jan, 2014 | Pubmed ID: 24122236 The Apoptotic and Proliferation Rate of Tumour Budding Cells in Colorectal Cancer Outlines a Heterogeneous Population of Cells with Various Impacts on Clinical Outcome Histopathology. Mar, 2014 | Pubmed ID: 24111856 Loss of Raf-1 Kinase Inhibitor Protein (RKIP) is Strongly Associated with High-grade Tumor Budding and Correlates with an Aggressive Phenotype in Pancreatic Ductal Adenocarcinoma (PDAC) Journal of Translational Medicine. 2013 | Pubmed ID: 24330423 Loss of Cdx2 Expression in Primary Tumors and Lymph Node Metastases is Specific for Mismatch Repair-Deficiency in Colorectal Cancer Frontiers in Oncology. 2013 | Pubmed ID: 24130965 High Myeloperoxidase Positive Cell Infiltration in Colorectal Cancer is an Independent Favorable Prognostic Factor PloS One. 2013 | Pubmed ID: 23734221 Next-generation Tissue Microarray (ngTMA) Increases the Quality of Biomarker Studies: an Example Using CD3, CD8, and CD45RO in the Tumor Microenvironment of Six Different Solid Tumor Types Journal of Translational Medicine. 2013 | Pubmed ID: 23627766 Clinical Impact of Programmed Cell Death Ligand 1 Expression in Colorectal Cancer European Journal of Cancer (Oxford, England : 1990). Jun, 2013 | Pubmed ID: 23478000 The Additional Facet of Immunoscore: Immunoprofiling As a Possible Predictive Tool for Cancer Treatment Journal of Translational Medicine. 2013 | Pubmed ID: 23452415 Tumor Budding Score Based on 10 High-power Fields is a Promising Basis for a Standardized Prognostic Scoring System in Stage II Colorectal Cancer Human Pathology. May, 2013 | Pubmed ID: 23159156 Proposal for a 10-high-power-fields Scoring Method for the Assessment of Tumor Budding in Colorectal Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Feb, 2013 | Pubmed ID: 23018875 Cancer Classification Using the Immunoscore: a Worldwide Task Force Journal of Translational Medicine. 2012 | Pubmed ID: 23034130 Characterization of CDKN2A(p16) Methylation and Impact in Colorectal Cancer: Systematic Analysis Using Pyrosequencing Journal of Translational Medicine. 2012 | Pubmed ID: 22925370 Role of Intra- and Peritumoral Budding in the Interdisciplinary Management of Rectal Cancer Patients International Journal of Surgical Oncology. 2012 | Pubmed ID: 22900161 The Impact of CpG Island Methylator Phenotype and Microsatellite Instability on Tumour Budding in Colorectal Cancer Histopathology. Nov, 2012 | Pubmed ID: 22803799 Diagnostic Reproducibility of Tumour Budding in Colorectal Cancer: a Multicentre, Multinational Study Using Virtual Microscopy Histopathology. Jul, 2012 | Pubmed ID: 22765314 Metastases and Primary Tumors Around Dental Implants: A Literature Review and Case Report of Peri-implant Pulmonary Metastasis Quintessence International (Berlin, Germany : 1985). Jul-Aug, 2012 | Pubmed ID: 22670251 Stratification and Prognostic Relevance of Jass's Molecular Classification of Colorectal Cancer Frontiers in Oncology. 2012 | Pubmed ID: 22655257 Intra-tumoral Budding in Preoperative Biopsy Specimens Predicts Lymph Node and Distant Metastasis in Patients with Colorectal Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Jul, 2012 | Pubmed ID: 22481282 Standardization of Whole Slide Image Morphologic Assessment with Definition of a New Application: Digital Slide Dynamic Morphometry Journal of Pathology Informatics. 2011 | Pubmed ID: 22200031 Characterization of the Immunological Microenvironment of Tumour Buds and Its Impact on Prognosis in Mismatch Repair-proficient and -deficient Colorectal Cancers Histopathology. Sep, 2011 | Pubmed ID: 22034888 VEGFA Gene Locus (6p12) Amplification Identifies a Small but Highly Aggressive Subgroup of Colorectal Cancer [corrected] Patients Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Oct, 2011 | Pubmed ID: 21743435 Intratumoral Budding As a Potential Parameter of Tumor Progression in Mismatch Repair-proficient and Mismatch Repair-deficient Colorectal Cancer Patients Human Pathology. Dec, 2011 | Pubmed ID: 21664647 Systematic Analysis of Proteins from Different Signaling Pathways in the Tumor Center and the Invasive Front of Colorectal Cancer Human Pathology. Dec, 2011 | Pubmed ID: 21664646 Comprehensive Analysis of CpG Island Methylator Phenotype (CIMP)-high, -low, and -negative Colorectal Cancers Based on Protein Marker Expression and Molecular Features The Journal of Pathology. Nov, 2011 | Pubmed ID: 21660972 The Medical Mystery of Napoleon Bonaparte: an Interdisciplinary Exposé Advances in Anatomic Pathology. Mar, 2011 | Pubmed ID: 21326012 Co-overexpression of P21 and Ki-67 in Head and Neck Squamous Cell Carcinoma Relative to a Significantly Poor Prognosis Head & Neck. Feb, 2011 | Pubmed ID: 20848449 Tumor Infiltration by FcγRIII (CD16)+ Myeloid Cells is Associated with Improved Survival in Patients with Colorectal Carcinoma International Journal of Cancer. Journal International Du Cancer. Jun, 2011 | Pubmed ID: 20715106 Epithelial Mesenchymal Transition and Tumor Budding in Aggressive Colorectal Cancer: Tumor Budding As Oncotarget Oncotarget. Nov, 2010 | Pubmed ID: 21317460 TIA-1 Cytotoxic Granule-associated RNA Binding Protein Improves the Prognostic Performance of CD8 in Mismatch Repair-proficient Colorectal Cancer PloS One. 2010 | Pubmed ID: 21179245 Tumor Budding Predicts Response to Anti-EGFR Therapies in Metastatic Colorectal Cancer Patients World Journal of Gastroenterology : WJG. Oct, 2010 | Pubmed ID: 20939111 Systematic Assessment of Protein Phenotypes Characterizing High-grade Tumour Budding in Mismatch Repair-proficient Colorectal Cancer Histopathology. Aug, 2010 | Pubmed ID: 20716165 Expression of P16 in Lymph Node Metastases of Adjuvantly Treated Stage III Colorectal Cancer Patients Identifies Poor Prognostic Subgroups: a Retrospective Analysis of Biomarkers in Matched Primary Tumor and Lymph Node Metastases Cancer. Oct, 2010 | Pubmed ID: 20572035 Role of Tumor Size in the Pre-operative Management of Rectal Cancer Patients BMC Gastroenterology. 2010 | Pubmed ID: 20550703 The Loss of the CBX7 Gene Expression Represents an Adverse Prognostic Marker for Survival of Colon Carcinoma Patients European Journal of Cancer (Oxford, England : 1990). Aug, 2010 | Pubmed ID: 20542683 Archaeology Dig into the Duodenal Biopsy Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. Jul, 2010 | Pubmed ID: 20471923 Role of the VEGF Ligand to Receptor Ratio in the Progression of Mismatch Repair-proficient Colorectal Cancer BMC Cancer. 2010 | Pubmed ID: 20222950 Combined Analysis of Specific KRAS Mutation, BRAF and Microsatellite Instability Identifies Prognostic Subgroups of Sporadic and Hereditary Colorectal Cancer International Journal of Cancer. Journal International Du Cancer. Dec, 2010 | Pubmed ID: 20162668 ABCG5-positivity in Tumor Buds is an Indicator of Poor Prognosis in Node-negative Colorectal Cancer Patients World Journal of Gastroenterology : WJG. Feb, 2010 | Pubmed ID: 20135722 Clinicopathological and Protein Characterization of BRAF- and K-RAS-mutated Colorectal Cancer and Implications for Prognosis International Journal of Cancer. Journal International Du Cancer. Jul, 2010 | Pubmed ID: 19908233 High Frequency of Tumor-infiltrating FOXP3(+) Regulatory T Cells Predicts Improved Survival in Mismatch Repair-proficient Colorectal Cancer Patients International Journal of Cancer. Journal International Du Cancer. Jun, 2010 | Pubmed ID: 19856313 Urokinase-type Plasminogen Activator is a Marker of Aggressive Phenotype and an Independent Prognostic Factor in Mismatch Repair-proficient Colorectal Cancer Human Pathology. Jan, 2010 | Pubmed ID: 19740518 Is the Improved Prognosis of P16 Positive Oropharyngeal Squamous Cell Carcinoma Dependent of the Treatment Modality? International Journal of Cancer. Journal International Du Cancer. Mar, 2010 | Pubmed ID: 19697324 Invasive Front of Colorectal Cancer: Dynamic Interface of Pro-/anti-tumor Factors World Journal of Gastroenterology : WJG. Dec, 2009 | Pubmed ID: 20014453 Systematic Assessment of the Prognostic Impact of Membranous CD44v6 Protein Expression in Colorectal Cancer Histopathology. Nov, 2009 | Pubmed ID: 19912362 Combined Histomorphologic and Immunohistochemical Phenotype to Predict the Presence of Vascular Invasion in Colon Cancer Diseases of the Colon and Rectum. Jun, 2009 | Pubmed ID: 19581855 Tumor Border Configuration Added to TNM Staging Better Stratifies Stage II Colorectal Cancer Patients into Prognostic Subgroups Cancer. Sep, 2009 | Pubmed ID: 19517467 Is Immunohistochemical Epidermal Growth Factor Receptor Expression Overestimated As a Prognostic Factor in Head-neck Squamous Cell Carcinoma? A Retrospective Analysis Based on a Tissue Microarray of 365 Carcinomas Human Pathology. Oct, 2008 | Pubmed ID: 18620726 Differential Diagnostic and Functional Role of the Multi-marker Phenotype CDX2/CK20/CK7 in Colorectal Cancer Stratified by Mismatch Repair Status Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Nov, 2008 | Pubmed ID: 18587323 RHAMM, P21 Combined Phenotype Identifies Microsatellite Instability-high Colorectal Cancers with a Highly Adverse Prognosis Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2008 | Pubmed ID: 18559599 Local Recurrence in Mismatch Repair-proficient Colon Cancer Predicted by an Infiltrative Tumor Border and Lack of CD8+ Tumor-infiltrating Lymphocytes Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2008 | Pubmed ID: 18559598 Chromosomal Instability in Gastric Mucosa-associated Lymphoid Tissue Lymphomas: a Fluorescent in Situ Hybridization Study Using a Tissue Microarray Approach Human Pathology. Apr, 2008 | Pubmed ID: 18234275 Node-negative Colorectal Cancer at High Risk of Distant Metastasis Identified by Combined Analysis of Lymph Node Status, Vascular Invasion, and Raf-1 Kinase Inhibitor Protein Expression Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2008 | Pubmed ID: 18172264 Multimarker Phenotype Predicts Adverse Survival in Patients with Lymph Node-negative Colorectal Cancer Cancer. Feb, 2008 | Pubmed ID: 18076013 Value of Staining Intensity in the Interpretation of Immunohistochemistry for Tumor Markers in Colorectal Cancer Virchows Archiv : an International Journal of Pathology. Oct, 2007 | Pubmed ID: 17674041 Loss of Raf-1 Kinase Inhibitor Protein Expression is Associated with Tumor Progression and Metastasis in Colorectal Cancer American Journal of Clinical Pathology. May, 2007 | Pubmed ID: 17439843 Close Association Between HER-2 Amplification and Overexpression in Human Tumors of Non-breast Origin Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Feb, 2007 | Pubmed ID: 17361205 Loss of APAF-1 Expression is Associated with Tumour Progression and Adverse Prognosis in Colorectal Cancer European Journal of Cancer (Oxford, England : 1990). Apr, 2007 | Pubmed ID: 17350821 Prognostic Significance of Mammalian Sterile20-like Kinase 1 in Colorectal Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Mar, 2007 | Pubmed ID: 17277767 Differential Significance of Tumour Infiltrating Lymphocytes in Sporadic Mismatch Repair Deficient Versus Proficient Colorectal Cancers: a Potential Role for Dysregulation of the Transforming Growth Factor-beta Pathway European Journal of Cancer (Oxford, England : 1990). Feb, 2007 | Pubmed ID: 17223543 Napoleon Bonaparte's Gastric Cancer: a Clinicopathologic Approach to Staging, Pathogenesis, and Etiology Nature Clinical Practice. Gastroenterology & Hepatology. Jan, 2007 | Pubmed ID: 17203089 Selecting Immunohistochemical Cut-off Scores for Novel Biomarkers of Progression and Survival in Colorectal Cancer Journal of Clinical Pathology. Oct, 2007 | Pubmed ID: 17182662 Prognostic Value of Cell Cycle and Apoptosis Regulatory Proteins in Mismatch Repair-proficient Colorectal Cancer: a Tissue Microarray-based Approach American Journal of Clinical Pathology. Jan, 2007 | Pubmed ID: 17145638 Construction and Validation of a Bone Marrow Tissue Microarray Journal of Clinical Pathology. Jan, 2007 | Pubmed ID: 16698953 Role of the Mitogen-activated Protein Kinase and Phosphoinositide 3-kinase/AKT Pathways Downstream Molecules, Phosphorylated Extracellular Signal-regulated Kinase, and Phosphorylated AKT in Colorectal Cancer-a Tissue Microarray-based Approach Human Pathology. Aug, 2006 | Pubmed ID: 16867865 Overexpression of the Receptor for Hyaluronic Acid Mediated Motility is an Independent Adverse Prognostic Factor in Colorectal Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Oct, 2006 | Pubmed ID: 16763611 Scoring of P53, VEGF, Bcl-2 and APAF-1 Immunohistochemistry and Interobserver Reliability in Colorectal Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Sep, 2006 | Pubmed ID: 16741523 EphB2 Expression Across 138 Human Tumor Types in a Tissue Microarray: High Levels of Expression in Gastrointestinal Cancers Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2005 | Pubmed ID: 16166419 Patterns of Gene Amplification in Gastrointestinal Stromal Tumors (GIST) Laboratory Investigation; a Journal of Technical Methods and Pathology. Jul, 2005 | Pubmed ID: 15864317 Proposal of a Morphologic Bone Marrow Response Score for Imatinib Mesylate Treatment in Chronic Myelogenous Leukemia Human Pathology. Jan, 2005 | Pubmed ID: 15712187 Prevalence of KIT Expression in Human Tumors Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Nov, 2004 | Pubmed ID: 15542802 Hepatocyte Paraffin 1 Expression in Human Normal and Neoplastic Tissues: Tissue Microarray Analysis on 3,940 Tissue Samples American Journal of Clinical Pathology. Nov, 2004 | Pubmed ID: 15491968 Nonsense-mediated Decay Microarray Analysis Identifies Mutations of EPHB2 in Human Prostate Cancer Nature Genetics. Sep, 2004 | Pubmed ID: 15300251 Frequent EpCam Protein Expression in Human Carcinomas Human Pathology. Jan, 2004 | Pubmed ID: 14745734 Macrofollicular Variant of Papillary Carcinoma of the Thyroid: a Histologic, Cytologic, and Immunohistochemical Study of 3 Cases and Review of the Literature Archives of Pathology & Laboratory Medicine. Jan, 2004 | Pubmed ID: 14692811 Expression of B-cell Markers in Classical Hodgkin Lymphoma: a Tissue Microarray Analysis of 330 Cases Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Nov, 2003 | Pubmed ID: 14614054 Calretinin Expression in Human Normal and Neoplastic Tissues: a Tissue Microarray Analysis on 5233 Tissue Samples Human Pathology. Oct, 2003 | Pubmed ID: 14608532 High-throughput Tissue Microarray Analysis of G1-cyclin Alterations in Classical Hodgkin's Lymphoma Indicates Overexpression of Cyclin E1 The Journal of Pathology. Feb, 2003 | Pubmed ID: 12533833 A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies Inti Zlobec1, Guido Suter1, Aurel Perren1, Alessandro Lugli1 1Institute of Pathology, University of Bern JoVE 51893 Medicine
A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies Inti Zlobec1, Guido Suter1, Aurel Perren1, Alessandro Lugli1 1Institute of Pathology, University of Bern JoVE 51893 Medicine